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Associate Director, Medicinal Chemistry

Company: Ensem Therapeutics
Location: Medford
Posted on: May 13, 2022

Job Description:

Associate Director, Medicinal ChemistryABOUT ENSEM THERAPEUTICS:ENSEM Therapeutics ("ENSEM") is a Boston-based, preclinical stage biopharmaceutical company focused on high value and difficult-to-drug targets in oncology to address unmet medical needs. The name ENSEM symbolizes innovations via the integration of groundbreaking technologies to decipher structural ENSEMbles and kinetics for drug design. The company's mission is to discover, develop, and commercialize transformative oncology therapies for patients, while leading the advancement of AI-driven structural ensemble and computational drug design.
PLEASE NOTE: This role will be moving to Waltham in August.
Position:Ensem is searching for an -Associate Director -to join our medicinal chemistry department. We are seeking a highly motivated and energetic medicinal chemist with extensive experience working on an integrated/multidisciplinary drug discovery team. -The successful candidate will be responsible for driving medicinal chemistry efforts in a fast-paced small molecule discovery research team through Hit ID, Lead Generation (LG), Lead Optimization (LO), and compound selection as a chemistry/project leader. Applicants should have broad medicinal chemistry experience from hit ID to development compound selection and track -record of innovation and creative problem solving. -The individual should be an expert in organic chemistry and possess broad scientific knowledge of state-of-the-art principles and theories in medicinal chemistry. The candidate should have deep -understanding of molecular properties and DMPK concepts that lead to the discovery of high-quality molecules. -The individual will be expected to participate in the writing and execution of patent applications, and interface with or lead internal cross-functional teams and external collaborators as well as CROs.PRINCIPAL RESPONSIBILITIES - - - - - - - -Provide innovative and effective leadership in medicinal chemistry from hit ID through clinical candidate selection - - - - - - - -Co-lead a drug discovery project team with a biology co-leader to drive every aspect of the project including scientific decisions and budgetary proposals - - - - - - - -Responsible for the success of the chemistry aspects of the drug discovery team through individual contributions and leading an external chemistry team - - - - - - - -Develop strong design solutions to medicinal and synthetic chemistry challenges - - - - - - - -Develop and ensure high quality and effective interactions cross functionally to support and achieve project goals and objectives - - - - - - - -Planning and effectively employing external chemistry resources to deliver high quality compounds for biological evaluationDESIRED SKILLS AND EXPERIENCE - - - - - -Ph.D. in Organic Chemistry, Medicinal Chemistry or related field - - - - - - - -6-12 years industrial experience as a medicinal chemist in a pharmaceutical or biotech company - - - - - - - -Demonstrated success in leading chemistry and projects teams to deliver high quality compounds into development - - - - - - - -Expert in medicinal chemistry from hit ID to compound selection with broad and in-depth knowledge of drug discovery and related disciplines (i.e. ADME, DMPK, toxicology, etc) with a connection to the laboratory. - - - - - - - -Proficient and knowledgeable in SAR, FBDD, SBDD and other medicinal chemistry platforms, yet possesses the intuition of a drug hunter - - - - - - - -Expert in synthetic organic chemistry with creative imagination to design, synthesize novel chemotypes and solve synthetic chemistry challenges - - - - - - - -Experience in leading drug discovery projects from hit ID to development is a must - - - - - - - -Experience understanding and writing patent applications - - - - - - - -Excellent organization skills as an individual contributor AND in leading or co-leading multidisciplinary drug discovery project teams are desired - - - - - - - -Ability to work independently and influence decision making within cross-functional teams - - - - - - - -Organized, results-driven, detail-oriented, and able to multi-task - - - - - - - -Highly motivated individual willing to go above and beyond to be successful and to be a key contributor in a highly innovative company - - - - - - - -Strong verbal communication and writing skills are requiredENSEM Therapeutics is an Equal Opportunity employer and does not discriminate against an applicant or employee because of race, creed, color, religion, sex, national origin, ancestry, age, sexual orientation, physical or mental disability, or veteran status.
The duties listed in this job description are intended only as illustrations of the various types of work that may be performed. The omission of specific statements of duties does not exclude them from the position if the work is similar, related, or a logical assignment to the position.

Keywords: Ensem Therapeutics, Medford , Associate Director, Medicinal Chemistry, Executive , Medford, Massachusetts

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