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Research Associate, Downstream Process Development

Company: GreenLight Biosciences, Inc.
Location: Medford
Posted on: January 9, 2022

Job Description:

ABOUT GREENLIGHT GreenLight Biosciences solves big problems facing society in agriculture, human health, and animal health through scientific innovation. GreenLight Biosciences is dedicated to bringing our cell-free RNA production process to market. Our work will lead to more sustainable global development, and we promise to deliver our safe solution without compromising the Earth and its people. One of the small coterie of early RNA-focused biotech startups, GreenLight Biosciences was founded in 2008, raised its-- -most recent round this year-- -and has a broad portfolio addressing key issues in plant health and human health. The GreenLight team is over 200 people across our headquarters in Medford, MA, an R&D facility in Woburn, MA and an R&D facility in Research Triangle Park, NC. GreenLight also has a pilot scale biomanufacturing plant in Rochester, NY. Initiatives include finding ways to support biodiversity,-- -protect bees and other pollinators, treat rare diseases such as-- -Sickle Cell Disease-- -as well as develop-- -vaccines for seasonal flu and the current COVID-19 pandemic.-- - At-- -GreenLight, we believe inclusion is the way forward. We celebrate the power of working together to address humanity's challenges, meet the needs of underserved populations, and push the boundaries of scientific discovery.-- -Fueled by our aspiration-- -for-- -a-- -true-- -sense of belonging, our talented teams embody the principles of diversity and equality as we strive to bring food security, medicine, and healthcare to everyone"-- - -paving the way for a sustainable future.-- -For more information, visit POSITION GreenLight Biosciences Inc. is seeking an exceptional, highly motivated Research Associate to contribute to the development of its cutting-edge mRNA production platform for vaccine and therapeutic applications. The successful candidate will work as part of the team responsible for producing materials for preclinical studies and discovery efforts, as well as developing scalable, robust processes suitable for clinical and commercial manufacturing. A deep technical background in chromatography, solid-liquid separations, clarification and tangential flow filtration is required. Strong technical, organizational, and communication skills, as well as the ability to work well on an agile and fast-moving team, are essential. MAJOR RESPONSIBILITIES As part of the downstream process development team, support the design and validation of downstream process conditions through resin and filter screening to identify optimal primary recovery, chromatography capture and polishing, and TFF steps for DNA plasmid and RNA products. Work in collaboration with discovery and preclinical teams to produce raw materials and mRNA products to support in vitro and in vivo preclinical studies. Support multiscale primary recovery, chromatography and TFF process validation studies to assess process suitability for clinical and commercial manufacturing. Support evaluation of downstream process robustness through risk assessments, DOE approaches, characterization, and in-process control evaluation in collaboration with MSAT and manufacturing teams. Maintain diligent and organized records. Clearly communicate results and recommendations to colleagues, team members, and supervisors to support process development decision-making. PROFESSIONAL EXPERIENCE / QUALIFICATIONS B.S. or M.S. in chemical engineering, bioengineering, biochemistry, biophysics, biology, or related discipline with 2-4 or 0-2 years of experience, respectively (title can be adjusted based on experience) Relevant downstream process development experience in the biotechnology or biopharmaceutical industry is highly desired Experience with multiple chromatography modalities, column packing and validation, AKTA purifiers and Unicorn software is a plus Understanding of standard molecular biology techniques, including characterization of nucleic acids and proteins is a plus Strong organization, communication, and interpersonal skills are required, with the ability to work both independently and in a collaborative work environment is required Please note: this is a full-time laboratory position and as such, physical presence at the GreenLight worksite is an essential job function of this role. Greenlight Biosciences Inc. provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation, and training. GreenLight requires proof of COVID-19 vaccination for its employees consistent with OSHA guidelines. -- -

Keywords: GreenLight Biosciences, Inc., Medford , Research Associate, Downstream Process Development, Other , Medford, Massachusetts

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