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Scientist, Analytical Sciences

Company: GreenLight Biosciences, Inc.
Location: Medford
Posted on: January 16, 2022

Job Description:

ABOUT GREENLIGHT GreenLight Biosciences solves big problems facing society in agriculture, human health, and animal health through scientific innovation. GreenLight Biosciences is dedicated to bringing our cell-free RNA production process to market. Our work will lead to more sustainable global development, and we promise to deliver our safe solution without compromising the Earth and its people. One of the small coterie of early RNA-focused biotech startups, GreenLight Biosciences was founded in 2008, raised its-- -most recent round this year-- -and has a broad portfolio addressing key issues in plant health and human health. The GreenLight team is over 200 people across our headquarters in Medford, MA, an R&D facility in Woburn, MA and an R&D facility in Research Triangle Park, NC. GreenLight also has a pilot scale biomanufacturing plant in Rochester, NY. Initiatives include finding ways to support biodiversity,-- -protect bees and other pollinators, treat rare diseases such as-- -Sickle Cell Disease-- -as well as develop-- -vaccines for seasonal flu and the current COVID-19 pandemic.-- - At-- -GreenLight, we believe inclusion is the way forward. We celebrate the power of working together to address humanity's challenges, meet the needs of underserved populations, and push the boundaries of scientific discovery.-- -Fueled by our aspiration-- -for-- -a-- -true-- -sense of belonging, our talented teams embody the principles of diversity and equality as we strive to bring food security, medicine, and healthcare to everyone"-- - -paving the way for a sustainable future.-- -For more information, visit POSITION We have an opening in our R&D team and are seeking an exceptional, highly motivated Scientist to play a key role in providing analytical support for the R&D Team. This Scientist will work within the Analytical Chemistry division will partner with process development at Greenlight. The role will focus on generation and implementation of accurate, precise, and reliable assays. Responsibilities include development and execution of sample extraction methods, traditional biochemical methods (e.g., gels, plates, blots), HPLC, LC-MS, IC, & CE methods, along with corresponding data analysis. Strong technical, organizational, and communication skills, along with a commitment to excellence and high-quality work are required. MAJOR RESPONSIBILITIES Coordinate and manage relationships with process development, sample generation, and formulations team Supervise assays to quantify and characterize plasmid DNA, measure bacterial endotoxin, and determine total microbial counts (with strong focus on plate-based assays, Agarose gels, CE, and SDS-PAGE techniques) Supervise assays to quantify process intermediates, including host cell protein and residual nucleic acids (RNA & DNA) Ascertain assay robustness, reproducibility, and determine if it is fit-for-purpose Develop & execute HPLC and CE analytical methods for the quantification analytes from complex matrices, such as crude cell lysates & finished product formulations Operate and maintain analytical instrumentation, including HPLC/UPLC/IC systems, QQQ and high resolution mass spectrometers, high-throughput capillary electrophoresis systems, and automated liquid handlers Evaluate various analytical techniques and instrumentation to deliver improved methods for the characterization of various analytes Apply DOE methodology to optimize assays for minimal CV and increased reproducibility Ensure accuracy of data and timely turnaround of results coming out of the Analytical Chemistry group Analyze, summarize, and present technical data to manager and other team members Work collaboratively with other R&D team members to accomplish project goals and milestones Strong attention to detail, problem solving abilities and a willingness to help wherever needed Stay up to date with scientific and technical development within the field of analytical chemistry PROFESSIONAL EXPERIENCE / QUALIFICATIONS Ph.D. or M.S. in analytical chemistry, chemistry, biochemistry, chemical engineering, or related field 4+ years' experience, preferably in an analytical chemistry group at an industrial biotechnology company; relevant graduate research will be considered Strong background in chemistry, with knowledge of nucleic acid chemistry, biochemistry, and microbial metabolism a plus Method development experience, with a proven track record of successfully developing sample extraction methods and robust, assay development Experience with nucleotide and oligonucleotide / nucleic acid separations is preferred Hands on experience troubleshooting analytical equipment is a plus Greenlight Biosciences Inc. provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation, and training. GreenLight requires proof of COVID-19 vaccination for its employees consistent with OSHA guidelines. -- -

Keywords: GreenLight Biosciences, Inc., Medford , Scientist, Analytical Sciences, Other , Medford, Massachusetts

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