Scientist, Biophysics, Silk Core R&D

Company: Evolved By Nature
Location: Medford
Posted on: November 16, 2022

Job Description:

Due to the company's expansive portfolio growth, the Evolved -By -Nature -Research and Development team is looking for a Scientist to join us in the biophysical characterization of novel silk compositions. In this role, you'll characterize and/or coordinate the biophysical characteristics of different silk compositions, structural dynamics and protein-protein interactions. Work will include the design of novel experiments. -Responsibilities:
--- - - - - -Design and execution of experiments in collaboration with the team--- - - - - -Work independently and in collaboration with the team--- - - - - -Analyze the physicochemical properties of the silk protein compositions internally or coordinate characterization with CROs--- - - - - -Develop novel assays to characterize protein-protein interactions, secondary and tertiary structure of proteins, peptides and complexes and their structural dynamics--- - - - - -Identify and prioritize critical experiments to accelerate the discovery and characterization of bioactive peptides--- - - - - -Constantly assess and implement new technologies/experimental approaches to the existing workflow to promote creativity and innovation--- - - - - -Perform kinetics analysis to support determination of Mechanism Of Action, IND filings, and therapeutic candidate selection.--- - - - - -Find solutions to experimental and technical issues as they arise--- - - - - -Deliver results within strict deadlines--- - - - - -Prepare detailed reports to share during project team meetings and at group meetings with clear and high quality/effective figures--- - - - - -Ensure accurate record keeping of all research work, generate progress reports and presentations in a timely manner--- - - - - -Participate in the preparation of presentations and manuscripts for publication--- - - - - -Engage with project team members from various cross-functional teams
Qualifications:------ - - - - -PhD preferred in in biological sciences/biophysics/biochemistry/chemistry with a focus on protein biophysical characterization with 0-3 years of hands-on experience working with proteins (or Master's Degree plus 2-5 years of experience or Bachelor's Degree plus 5-8 years of experience).
Skills & Abilities: -Essential:
--- - - - - -Expertise in biologics/protein characterization including deep understanding of binding kinetics using SPR, DSF, MST and other orthogonal protein-protein interaction methods.--- - - - - -Solid technical foundation in protein chemistry/biochemistry lab processes--- - - - - -Experience with standard protein handling/analysis methods like SDS-PAGE, Coomassie/silver staining, concentration determination, dialysis--- - - - - -Demonstrated ability to communicate complex scientific concepts to domain experts and non-experts across the organization, using clear figures and presentations--- - - - - -Demonstrated evidence of technical writing skills to summarize and keep an accurate record of experiments performed--- - - - - -Equally comfortable working independently and with a team--- - - - - -Very high communication skills with subject matter specialists and non-specialists--- - - - - -Energetic and creative problem-solver who thrives in an innovative environment, adapts to change, and can grasp new concepts and techniques quickly--- - - - - -Proficiency with Office software (Word, Excel, PowerPoint) or Pages, Keynote and Numbers -Desirable:
--- - - - - -Experience working with proteins that exhibit complex behaviors (solubility, sample complexity, physicochemical properties)--- - - - - -Experience working with natively intrinsic/unfolded protein and determining their dynamic--- - - - - -Experience with in vitro reconstitution of protein function--- - - - - -Experience with technologies to characterize 2D 3D protein and protein complex structure (X-ray, NMR etc.)--- - - - - -Experience with GraphPad Prism, Adobe Photoshop/Illustrator, NCBI, RSCB, Pymol or other protein visualization--- - - - - -Experience with protein analysis techniques like Dynamic Light Scattering, Wyatt DLS/RI, Isoelectric Focusing gel analysis--- - - - - -Experience with High Performance Liquid Chromatography (HPLC)--- - - - - -Demonstrated experience with all/some of the above through publications in peer-reviewed journals, patents, conference proceedings or research thesis.
Other Requirements: -

• Able to obtain up to date Covid-19 vaccination status per the current CDC guidelines (full vaccination dose and booster) prior to employment start day. - - - -Evolved By Nature is a new type of biotech company creating new molecules for a healthier future. With a belief that the next generation of products will advance the health of people and planet, we're using -our sustainable molecule platform, Activated Silk--- technology, to create biomolecules, sustainable chemicals and natural ingredients that will increase the performance and decrease -the environmental impact of everything from therapeutics to soap, to sneakers.

Keywords: Evolved By Nature, Medford , Scientist, Biophysics, Silk Core R&D, Other , Medford, Massachusetts